Showing posts with label Genentech. Show all posts
Showing posts with label Genentech. Show all posts

Monday, July 24, 2017

200,000 Pageviews

On or about July 17, 2017, this blog tallied its 200,000th page view. Launched on 2 January 2011, about 100 people per day read the posts, often as a result of Internet searches for topical information. Everyone can be a publisher, and perhaps too many people are. But I believe that we are experiencing a renaissance, a silver age, if not a golden age, in which the sharing of information – facts and opinions alike — creates a flourishing. Our lives are better.

In a previous post, I wrote about Jerry Emanuelson’s algebraic proof of Ricardo’s Law of Comparative Advantage. Emanuelson has other interests. He previously created and marketed a high school level kit for experimenting with superconductors. The Internet gave him an easy and extensive exposure.


Science hobbyists of our generation knew well the Edmund Scientific Catalog. Edmund also wrote about the scientific method. He taught it as a 14-step engagement in discovery. Norman W. Edmund lived long enough (1916-2012) to bring his work to the Internet (see here http://scientificmethod.com/index2.html ). It proved much more efficient than the U.S. Post Office.

The most popular articles from this blog so far are:
What (if anything) did Dorothy Learn? (4626)
Contradictions in the Constitution (2400)
Alongside Night to Run in Austin (1799)
Bob Swanson and Genentech (713)
William Sheldon: Psychologist, Numismatist, Thief (655)
Debt: the Seed of Civilization (556)
Crimes Against Logic: Exposing Bogus Arguments (409)
There is no John Galt and that’s Worse (356)
Supplies and Demands (340)
Romantic Realism (339)


Those numbers come from the Stats under the All time button on my control panel. However, I also have other numbers under View Count in the Posts:

Forgery and Fraud in Numismatics 1187
Debt: the Seed of Civilization 1183
Harriman’s Logical Leap Almost Makes it 884
(see, also, David Harriman’s Logical Leap 408)
Junk Criminology as Pseudo-Science 877
Nerd Nation: Natalie Portman, Danika McKeller, and Felicia Day 831
Unlimited Constitutional Government 797
ELI the ICE Man: Science and Technology 788
Hacking Computer Security: BSides Austin 2013 747
Art & Copy 729
Megacities 726
… that goddam Ayn Rand book 717
To Make Money 658
The Problem of Induction: Karl Popper and His Enemies 643
Employee Theft 639
The Fallibility of Fingerprinting 634
Sándor Kőrösi Csoma 626
Murray Rothbard: Fraud or Faker? 592
Shifting the Paradigm of Private Security 569
Venture Capital 566
Where All Children are Above Average 556
Karl Marx and the Dustbin of History 553
Gregory M. Browne’s Necessary Factual Truths 529
Republicans for Voldemort 528
Ayn Rand versus Conservatives 527
Firefly: Fact and Value Aboard “Serenity” 517
De Magnete by William Gilbert 466
George Boole’s Laws of Thought 459
Money as Press and Speech 439
Money as Living History 433
Against Gulching 396
Ma Kiley: Railroad Telegrapher 367
Short Snorters 354
The Virtues of Aviation Culture 339
A Successful Imitation of Alan Turing 335

The search terms that bring people here include Çatal Hüyük, (catal huyuk), supply and demand, supply and demand curve, contradictions in the Constitution, Merry Newtomas, and Employee Theft Facts. Although I write about Newtonmas every year, none of them makes the top of the lists.

Mirror sites
Among others…

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Wednesday, July 3, 2013

Bob Swanson and Genentech

Money is a culture medium for growing viable enterprises into self-sustaining engines of creation. 

publicity photograph showing man in dark business suit holding a vial of medicine with laboratory workers behind himBob Swanson was 29 when he provided the money for Prof. Herbert Boyer to start Genentech.  Like all overnight successes, the real story is more complicated, with deep roots.  Bright, accomplished, and motivated, Swanson had obvious potential – and a string of failures to show for it.  In the documentary, Something Ventured (see below), Thomas J. Perkins said that his firm, Kleiner Perkins Venture Capital, brought on Bob Swanson, but “there was not much for him to do.”  Swanson said that he would look into biotechnology.  Perkins replied that if something was there, they would be interested, otherwise… And at that point, Perkins trailed off into a gesture and face.  Clues are always little things.
“So we hired Bob Swanson, whom Eugene Kleiner had known through venture capital circles. Bob had worked for Citibank in their venture capital operation and he and Eugene had been involved in a failed deal. Eugene had been impressed with Swanson's ability to think straight and get things done. So when Bob was looking for a new position, we hired him. That would have been about late 1974. We were in Embarcadero Center Two then, on the top floor.[…]  Bob worked on various deals for us. And, I have to say, not very successfully. Eugene, in particular, was increasingly unhappy with Bob. He didn't think much was going to be happening.” – Thomas Perkins [Source 5]
Robert A. Swanson was born in Brooklyn, New York, November 29 1947.  When he was still an infant, his family moved to Florida where his father worked for Eastern Airlines.  He attended MIT and completed his bachelor’s in chemistry in 1969 and followed that in 1970 with an MBA at the Sloan School of Management.  [Source 1] (Wikipedia gives 1970 as the year of both degrees.) 

Immediately after completing his MBA, he was hired by Citicorp Venture Capital.  Within three years, they were impressed enough with him that he was sent to San Francisco to open a Citicorp Venture Capital Office there.  In 1975, he joined Kleiner, Perkins, Caufield & Byers.  (Perkins recalled that as “late 1974.”) [Source 5]

Swanson had read about the research in recombinant DNA and gene splicing.  He sought out Dr. Boyer and asked for 10 minutes.  The two men spent three hours in a tavern.  Swanson’s knowledge of chemistry served him well, as he could understand the nuances in the different techniques being pursued by different researchers.  Swanson saw the market for Boyer’s work.  They launched Genentech on April 7, 1976. [Source 2]


In 1977, Genentech started with human growth hormone by contracting for production with City of Hope Hospital in Los Angeles and with the University of California at San Francisco. That allowed Genentech to move up to cloned human insulin in 1978.  They followed that with other successes: alpha interferon, gamma interferon, a hepatitis B vaccine, and thrombolytic (clot-producing) agents for hemophiliacs, and then tissue plasminogen activator (TPA) to dissolve blood clots associated with heart attacks.

America’s bilateral East Coast / West Coast dichotomies are easy to cite, especially in technology.  (In Hackers: Heroes of the Computer Revolution, Steven Levy pointed out that the Spacewars video game came from MIT, whereas Stanford gave us Adventure, based on Lord of the Rings.)  But Robert Swanson understood the importance of social capital, built with strong employee bonds.   His scientists could publish their work, something most big drug companies were reluctant to allow.  Also typical of the West Coast, Genentech held Friday parties known as ho-hos.  As Genentech researchers remembered it: 
“The Ho-Ho tradition began simply with refreshments for employees every Friday afternoon. At the end of one particularly hectic work week, a manufacturing VP said, "Oh, another Friday afternoon, ho, ho, ho, ho." And the name stuck. …
The Ho-Ho was an occasion for play and absurdity. One time Swanson and Boyer came dressed up as Tweedledee and Tweedledum… But from the start, Ho-Hos were more than just fun. To Swanson, the Ho-Ho was “a wonderful idea, because you need a place where people at all levels of the organization, from the president on down, can get together in their shirtsleeves and talk about the issues, as equals... One of the things you worry about, as you get higher in an organization, is whether people are comfortable telling you the truth about the way they see the needs of the company - where are we screwing up as a company?” 
The firm posted a profit in 1979 and went public in 1980. That public offering came at some human cost for the venture capitalists.  Perkins and Swanson disagreed on the timing, with Swanson being opposed to going public.  Eventually, Swanson saw Perkins’s point, but their strained relationship was worse off for it.  Still, Bob Swanson worked as CEO of Genentech through its steepest growth curve through 1990.  Tom Perkins was chairman of the board.  Then, from 1990-96 Swanson served as chairman.  In 1990, Genentech and Roche Holding Ltd. completed a $2.1 billion merger. Initially Hoffman-LaRoche bought a majority interest in Genentech. Then in 2009, LaRoche bought the rest of the stock, but turned around and sold off blocks of it in to the public.

After leaving Genentech Bob Swanson formed a private investment management firm (K & E Management), and served as chairman of Tularik, Inc., a firm researching gene expressions that can be harnessed to produced therapeutics. He also volunteered his time to civic organizations and to his daughters’ soccer teams.

In the book, 1,000 Years, 1,000 People: Ranking the Men and Women Who Shaped the Millennium, (New York :, Kodansha International, 1998) the authors ranked Bob Swanson number 612 for launching the biotechnology revolution.

After a year of battling brain cancer via surgery and chemotherapy Bob Swanson passed away on Monday, December 6, 1999, at his home in Hillsborough, California. (The Guardian gave it as November 30.)  He was 52.

Sources:
1. http://web.mit.edu/newsoffice/1999/swanson-1208.html (Obituary)
2. http://www.gene.com/about-us/leadership/our-founders (Tribute)
3. http://www.nytimes.com/1999/12/07/business/robert-a-swanson-52-co-founder-of-genentech.html (Obituary)
4. http://www.guardian.co.uk/science/1999/dec/10/obituaries.genetics (Biography)
5. http://content.cdlib.org/view?docId=kt1p3010dc (Program in the History of the Biological Sciences and Biotechnology: Kleiner Perkins, Venture Capital, and the Chairmanship of Genentech, 1976-1995; interviews conducted by Glenn E. Bugos, Ph.D.)
6. "The Origins of Biotechnology: A Genentech Perspective"
http://blog.zymergi.com/2013/01/origins-biotech-genentech.html
(Personal recollections and images of artifacts including company newsletters.)

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